| # | Team | P | W | D | L | GD | Pts |
|---|---|---|---|---|---|---|---|
| 1 |  Nashville SC | 33 | 22 | 8 | 3 | +44 | 74 |
| 2 |  Inter Miami CF | 33 | 16 | 11 | 6 | +21 | 59 |
| 3 |  New England Revolution | 33 | 18 | 4 | 11 | +9 | 58 |
| 4 |  Chicago Fire | 33 | 16 | 7 | 10 | +11 | 55 |
| 5 |  Charlotte FC | 33 | 15 | 8 | 10 | +15 | 53 |
| 6 |  Philadelphia Union | 33 | 13 | 8 | 12 | +11 | 47 |
| 7 |  FC Cincinnati | 33 | 12 | 10 | 11 | -6 | 46 |
| 8 |  Columbus Crew | 33 | 13 | 5 | 15 | +6 | 44 |
| 9 |  Orlando City | 33 | 12 | 7 | 14 | -16 | 43 |
| 10 |  New York Red Bulls | 33 | 11 | 6 | 16 | -17 | 39 |
