AEK Athens vs. Real Madrid
Venue: AEK Arena, Athens
Local Kick-off Time: Nov 4, 2026 7.45pm
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In the Champions League league stage, Real Madrid travel to Greece to face AEK Athens, aiming to preserve their 100% continental record. Jose Mourinho's side sit fourth in the standings with nine points from three matches, carrying a six-game winning streak in all competitions following a 3-0 win over Racing Santander and a 4-1 victory over RB Leipzig. Vinicius Junior is available to start on the left and Federico Valverde has returned to training, though Rodrygo (knee) and Raul Asencio (leg) remain sidelined. AEK Athens opened with a 1-0 win over LASK Linz before suffering heavy defeats to Shakhtar Donetsk (3-1) and Manchester City (5-1), leaving them 29th with three points. Marko Nikolic's men will be without Thomas Strakosha (hand), while Joao Mario and Lazaros Rota are doubtful through illness, with Luka Jovic and Barnabas Varga expected to lead the line.
Slavia Prague vs. Arsenal
Venue: Eden Arena, Prague
Local Kick-off Time: Nov 4, 2026 9.00pm
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Unbeaten Arsenal visit Fortuna Arena to take on Slavia Prague in the Champions League. Mikel Arteta's side have seven points from three games, bouncing back from an intense 2-2 draw at Bayern Munich by securing a landmark 1-0 victory against Liverpool at Anfield to sit three points clear atop the Premier League. The Gunners have conceded only twice in Europe, sharing the best defensive record alongside Stuttgart and PSV. Bukayo Saka remains out with a quad issue and Eberechi Eze faces a fitness concern, potentially opening the door for Max Dowman to feature. Slavia Prague sit 32nd with one point following an opening loss to Lens and Sabah before fighting back from 2-0 down to draw 2-2 at Fenerbahce. Ivan Schranz remains ill, Lukas Provod and Ange N'Guessan are fitness doubts, and striker Tomas Chory remains banished from the squad due to disciplinary issues.
RB Leipzig vs. Manchester City
Venue: RB Arena, Leipzig
Local Kick-off Time: Nov 4, 2026 9.00pm
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Manchester City travel to Germany to face Martin Demichelis's RB Leipzig looking to bounce back from domestic disappointment. Enzo Maresca's side sit 10th in the Champions League with six points (W2 L1), but enter this fixture following consecutive Premier League defeats, including a 1-0 home reverse against Brighton. City's only injury absentee is Antoine Semenyo (knee), with Phil Foden and Rayan Cherki pushing to start, alongside Erling Haaland, who has netted 12 goals in eight career matches against Leipzig. Die Roten Bullen sit 29th with three points after suffering 4-1 defeats to Como and Real Madrid alongside a 1-0 win over PSV. Domestically, Leipzig sit fourth in the Bundesliga after beating Schalke 04 2-0. Assan Ouedraogo and Marc Guiu are ruled out with injuries, Maxime Esteve is doubtful, and Christopher Nkunku remains under assessment.
Porto vs. Napoli
Venue: Estádio do Dragão, Porto
Local Kick-off Time: Nov 4, 2026 8.00pm
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Porto host Napoli at Estadio do Dragao in desperate need of points following three consecutive Champions League defeats against Manchester City, Real Betis, and PSV Eindhoven. Francesco Farioli's side have dominated domestically with 10 straight Primeira Liga wins, beating Estoril 4-0 over the weekend. William Gomes and Vasco Sousa remain injured, while Oskar Pietuszewski and Zaidu are doubts. Napoli sit on three points after edging a 4-3 thriller against Bodo/Glimt, but Massimiliano Allegri's side are winless in seven Champions League away games and sit eighth in Serie A following a 2-0 loss to Juventus. The Partenopei face extensive absences, with Alessandro Buongiorno, David Neres, Leonardo Spinazzola, Benoit Badiashile, and Stanislav Lobotka unavailable, Rasmus Hojlund battling flu, and both Giovanni Di Lorenzo and Mathias Olivera nursing muscular issues, though Kevin De Bruyne is set to feature despite an ankle sprain.
Borussia Dortmund vs. Real Betis
Venue: BVB Stadion Dortmund, Dortmund
Local Kick-off Time: Nov 4, 2026 9.00pm
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Borussia Dortmund welcome Real Betis to Signal Iduna Park in a meeting between two in-form sides. Niko Kovac's men sit 13th in the Champions League with six points following wins over Villarreal (3-2) and Sabah (2-1) alongside a 1-0 defeat to Bodo/Glimt. Unbeaten in their last five in all competitions following a 2-2 draw with Bayern Munich, BVB have won their last four UEFA home ties against Spanish clubs. Kaua Prates (muscle) is the only confirmed absentee, with Serhou Guirassy, Fabio Silva, and Jobe Bellingham set to feature. Manuel Pellegrini's Betis arrive boasting a flawless Champions League campaign with nine points from three games (beating Lille 3-2, Porto 3-2, and Feyenoord 1-0) and sit fourth in La Liga. Cucho Hernandez (calf) and Junior Firpo (muscle) are sidelined, while Isco, Marc Bartra, Abde Ezzalzouli, and Troy Parrott are in line to start.
Lens vs Como
Venue: Stade Bollaert-Delelis, Lens Agglo
Local Kick-off Time: Nov 4, 2026 9.00pm
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Lens welcome Como to Stade Bollaert-Delelis with the French side looking to make up ground against the Italian debutants in the Champions League. Cesc Fabregas's men sit on six points from three matches following an emphatic 4-1 victory over Manchester United, becoming the highest-scoring debutant side in the competition since 1973 with 10 goals. Unbeaten in their last five across all competitions after edging Venezia 1-0 to sit fourth in Serie A with a club-record 23 points from 10 games, Como arrive in formidable form. Moise Kean, Trevoh Chalobah, Jesus Rodriguez, and Assane Diao are ruled out with injuries, while Jayden Addai is a major doubt, leaving key figures Nico Paz and Tasos Douvikas to spearhead the attack. Yannick Cahuzac's Lens sit on three points outside the top 24 after following an opening 3-2 comeback win over Slavia Prague with defeats to Sporting Lisbon (2-0) and Club Brugge (3-0), extending their Champions League run without a clean sheet to 16 matches. Having slipped to ninth in Ligue 1 following a derby loss to Lille, Lens are without Ismaelo Ganiou, Maik Nawrocki, Abdallah Sima, and Odsonne Edouard (adductor surgery), while Jhoanner Chavez is doubtful, leaving Franjo Ivanovic in line to lead the line.